{"metadata":{"accession":"IPR003325","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"cdd":{"cd06974":"Uncharacterized proteins involved in stress response, similar to tellurium resistance terD"},"pfam":{"PF02342":"TerD domain"}},"integrated":null,"hierarchy":{"accession":"IPR003325","name":"TerD domain","type":"Domain","children":[]},"name":{"name":"TerD domain","short":"TerD"},"description":[{"text":"<p>The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins [[cite:PUB00008105], [cite:PUB00066658]]. It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium binding sites [[cite:PUB00066658], [cite:PUB00054628]] depending on the conservation of aspartates [[cite:PUB00066658]]. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways [[cite:PUB00066658]].</p>\n\n<p>TerD domain is also found in cAMP binding protein, chemical-damaging agent resistance proteins and general stress proteins. The cellular Slime mould, Dictyostelium discoideum, contains a cAMP-binding protein, CABP1, which is composed of two subunits. The C-terminal half of these subunits contain this domain [[cite:PUB00008106]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00008105":{"PMID":10203839,"ISBN":null,"volume":"7","issue":"3","year":1999,"title":"Bacterial tellurite resistance.","URL":null,"raw_pages":"111-5","medline_journal":"Trends Microbiol","ISO_journal":"Trends Microbiol.","authors":["Taylor DE."],"DOI_URL":"http://dx.doi.org/10.1016/S0966-842X(99)01454-7"},"PUB00008106":{"PMID":2176639,"ISBN":null,"volume":"96","issue":"2","year":1990,"title":"Cloning and characterization of cDNAs encoding a novel cyclic AMP-binding protein in Dictyostelium discoideum.","URL":null,"raw_pages":"213-8","medline_journal":"Gene","ISO_journal":"Gene","authors":["Grant CE","Tsang A."],"DOI_URL":"http://dx.doi.org/10.1016/0378-1119(90)90255-P"},"PUB00066658":{"PMID":23044854,"ISBN":null,"volume":"8","issue":"12","year":2012,"title":"Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing.","URL":null,"raw_pages":"3142-65","medline_journal":"Mol Biosyst","ISO_journal":"Mol Biosyst","authors":["Anantharaman V","Iyer LM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1039/c2mb25239b"},"PUB00054628":{"PMID":21112337,"ISBN":null,"volume":"405","issue":"5","year":2011,"title":"NMR Structure and Calcium-Binding Properties of the Tellurite Resistance Protein TerD from Klebsiella pneumoniae.","URL":null,"raw_pages":"1188-201","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Pan YR","Lou YC","Seven AB","Rizo J","Chen C."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2010.11.041"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":109,"interactions":0,"matches":31764,"pathways":0,"proteins":28424,"proteomes":3375,"sets":0,"structural_models":{"alphafold":18127,"bfvd":1},"structures":5,"taxa":6311},"entry_annotations":{"alignment:seed":166,"alignment:full":10087},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3ibz","name":"Crystal structure of putative tellurium resistant like protein (TerD) from Streptomyces coelicolor A3(2)"}}}