InterPro protein focus
Protein Focus (formally known as Protein of the Month) explores the function and family relationships of selected proteins from the InterPro database, aiming at a general audience. Each article introduces a different protein, exploring its biological function as it relates to other members of the protein family, examining common domain architectures and their biological distribution, and tying it in to a broader perspective on how the protein impacts today's medicine and the environment. The articles also serve as an introduction to the use of the InterPro database, exploring the relevant InterPro entries for each featured protein in detail, and relating them to the biological information discussed in the article. Links are provided to the PDB's Molecule of the Month, where the structural features of the proteins are explored in detail, and, when applicable, to the EXPASY Protein Spotlight to gain another view of the featured proteins.
Don’t blame the cat - the toxoplasmosis effect
The parasite Toxoplasma gondii, the causative agent of toxoplasmosis, manipulates the behavior of rodents to ensure reaching its definitive host: the cat. Here we explore the biological mechanisms deployed to 'control' the host, and how this game of cat and mouse could be affecting you.
Dionysian mysteries - the aldehyde dehydrogenase (ALDH) family
Do you have friends that cannot handle alcoholic drinks? Just half a pint of beer or a few sips of wine, and their faces turn red, possibly with some hangover symptoms? In this article, we will learn more about the mystery behind this condition.
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Bee afraid, bee very afraid - neonicotinoids and the nAChRs family
Bees are disappearing! The crisis is spreading around the world! To protect these important pollinators, the EU has proposed restricting the use of neonicotinoid pesticides. But what are neonicotinoids? And why were they chosen as pesticides in the first place? Let’s find out more in this article.
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Wilson’s disease and the copper ATPase transporters
In the American TV series House, episode 'The Socratic Method', a mother seeming to suffer from schizophrenia is admitted to hospital. Let’s find out how House solves this case and how we can use InterPro to know more about the Wilson’s disease protein and its homologues.
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Are we really related? The Rad9/Ddc1 family
Protein family classification is often achieved using computerised multiple protein sequence alignment and structural analysis. However, it's not always straightforward to define a protein family. In this article, we will take a look at an example-the Rad9/Ddc1 family.
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Relax and unwind: the RecQ DNA helicase family
When people go on holiday or travel for a conference, fitting all their clothes, books and a laptop into a small suitcase often presents a challenge. For eukaryotic cells, packing their lengthy genomic DNA into their relatively small nucleus presents a similar challenge.
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Killer toxin Protein (KP4): Harnessing the power of a killer toxin for good
The yeast killer toxin protein KP4 is currently used in agriculture as a means of protecting plants form fungal infections. There is an ever widening scope of the potential applications of this protein in biotechnology and medicine.
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Chemokine receptor type 4 (CXCR4): diseases, drugs and druggable target molecules
Chemokine Receptor type 4 (CXCR4) is of increasing interest as a drug target. This molecule is thought to be involved in many disease states including more than 23 types of cancer and several immunodeficiency disorders.
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Collagen: a ubiquitous, unsung protein
Collagen is a long, fibrous structural protein that is usually associated with cosmetic enhancements, movie star's lips and anti-aging lotions. Just as one hopes for these movie stars; there is much more to collagen than what appears on the surface. Collagen is the most abundant protein in mammals.
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October: Cytochrome P450
September: Elongation Factors
August: AAA ATPases
July: Amyloid-beta Precursor Protein
May: Glucose Oxidase and Biosensors
April: Bird Flu Haemagglutinin
January: DNA topoisomerase
December: ATP Synthase
November: Acetylcholine Receptors
September: Cholera Toxin
August: TRK Receptors
July: TATA-box Binding Proteins
June: Carotenoid oxygenase
May: Sm Ribonucleoproteins
March: T Cell receptors
February: Major Histocompatibility Complex (MHC)
January: Phenylalanine Hydroxylase
November: Photosystem II
October: G Proteins
July: DNA Ligase IV
June: Snake Venom: Bungarotoxins
May: Serpins: alpha-1 antitrypsin
April: Growth Hormone Receptors
March: Calcium Pumps
February: Enzymes of Glycolysis
January: Carbonic Anhydrase
December: Catabolite Activator Protein
November: Simian Virus 40
September: Oestrogen receptors
July: SRC, proto-oncogene tyrosine-protein kinase
June: Green fluorescent protein