Homologous Superfamily

Adenosylhomocysteinase-like superfamily (IPR042172)

Short name: Adenosylhomocyst_ase-like_sf

Overlapping entries


Structural domains found in this superfamily share the structure of the enzyme adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, AdoHcyase), which is formed in methylation and catalyses the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and a key regulator of the intracellular concentration of adenosylhomocysteine. In addition, this enzyme is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, and thus plays a critical role in the modulation of their activity [PMID: 9586999, PMID: 16061414, PMID: 11325033, PMID: 15165742].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.