Domain

Lipoxygenase, vertebrates, PLAT domain (IPR042062)

Short name: PLAT_LOX_verte

Overlapping homologous superfamilies

Domain relationships

  • PLAT/LH2 domain (IPR001024)
    • Lipoxygenase, vertebrates, PLAT domain (IPR042062)

Description

Lipoxygenases (LOXs, LOs) catalyze the the dioxygenation of polyunsaturated fatty acids, including arachidonic acid. Animal LO enzymes include 5-LO, 12-LO (epidermal-, platelet-, and leukocyte-type), 15-LO, and eLOX-3 (epidermis-type LO-3). 12-LO and 15-LO and its metabolites participate in apoptosis, autophagy and ferroptosis, and have been implicated in the development of insulin resistance and diabetes [PMID: 29627380, PMID: 22951339].

This entry represents the PLAT domain of vertebrate LOs [PMID: 10469604]. 12-LO and 15-LO are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates [PMID: 12106812, PMID: 10672019, PMID: 20970452].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD