Domain

Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 1 (IPR041880)

Short name: SAM_ANKS1_repeat1

Overlapping homologous superfamilies

Domain relationships

Description

This SAM (sterile alpha motif) domain repeat 1 of ANKS1 (also known as AIDA-1) is a protein-protein interaction domain.

Proteins contain this domain include ANKS1A (also known as Odin) and ANKS1B (also known as AIDA-1 or EB-1). ANKS1A modulates EGF receptor recycling and stability [PMID: 23825523]. ANKS1B may participate in the regulation of nucleoplasmic coilin protein interactions [PMID: 15862129]. Structurally, ANKS1 consist of N-terminal ankyrin motifs followed by two tandem sterile alpha motif (SAM) domains and a carboxyl phosphotyrosine binding (PTB) domain [PMID: 23825523]. SAM domains of ANKS1 can directly bind ubiquitin and participate in regulating the degradation of ubiquitinated EphA receptors, particularly EPH-A8 receptor [PMID: 20100865]. SAM1 domain has a potential phosphorylation site for CMGC group of serine/threonine kinases. The second SAM domain may decouple from the first SAM domain to facilitate translocation of AIDA-1 to the nucleus [PMID: 19666031].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
  • cd09499 (SAM_AIDA1AB-like_repeat1)