Ras-related protein Rap2 (IPR041840)

Short name: Rap2

Overlapping homologous superfamilies

Family relationships


This entry includes Rap2a/b/c, which is part of the Rap subfamily of the Ras family. Both isoform 3 of the human mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) and Traf2- and Nck-interacting kinase (TNIK) are putative effectors of Rap2 in mediating the activation of c-Jun N-terminal kinase (JNK) to regulate the actin cytoskeleton [PMID: 15342639, PMID: 14966141]. In human platelets, Rap2 was shown to interact with the cytoskeleton by binding the actin filaments [PMID: 10572250]. In embryonic Xenopus development, Rap2 is necessary for the Wnt/beta-catenin signaling pathway [PMID: 15706349]. The Rap2 interacting protein 9 (RPIP9) is highly expressed in human breast carcinomas and correlates with a poor prognosis, suggesting a role for Rap2 in breast cancer oncogenesis [PMID: 15986426]. Rap2b, but not Rap2a, Rap2c, Rap1a, or Rap1b, is expressed in human red blood cells, where it is believed to be involved in vesiculation [PMID: 16540189]. A number of additional effector proteins for Rap2 have been identified, including the RalGEFs RalGDS, RGL, and Rlf, which also interact with Rap1 and Ras [PMID: 10085114].

Most Ras proteins contain a lipid modification site at the C terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins [PMID: 16543601].

GO terms

Biological Process

GO:0032486 Rap protein signal transduction

Molecular Function

GO:0003924 GTPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.