Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain (IPR041715)

Short name: HisRS-like_core

Overlapping homologous superfamilies


Domain relationships


HisRS is a homodimer and is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs [PMID: 12269828]. This domain is also found at the C terminus of eukaryotic GCN2 protein kinase [PMID: 7623840] and at the N terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain [PMID: 10430882].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.