Domain

Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain (IPR041689)

Short name: GBR2_CC

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This is the intracellular coiled-coil domain found in Gamma-aminobutyric acid type B receptor subunit 2 (GBR2). The coiled-coil complex between the GABAB receptor subunits GBR1 and GBR2 is responsible for facilitating the surface transport of the intact receptor. Disruption of the hydrophobic coiled-coil interface with single mutations in either subunit impairs surface expression of GBR1, confirming that the coiled-coil interaction is required to inactivate the adjacent ER retention signal of GBR1 [PMID: 24778228].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam