Domain

Desmoplakin, SH3 domain (IPR041615)

Short name: Desmoplakin_SH3

Overlapping homologous superfamilies

None.

Domain relationships

  • SH3 domain (IPR001452)
    • Desmoplakin, SH3 domain (IPR041615)

Description

This entry represents the SH3 domain found in Desmoplakin and related proteins [PMID: 21536047].

Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs). Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle [PMID: 21536047].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam