Cop9 signalosome subunit 5 C-terminal domain (IPR040961)

Short name: CSN5_C

Overlapping homologous superfamilies


Domain relationships



The COP9 (Constitutive photomorphogenesis 9) signalosome (CSN), a large multiprotein complex that resembles the 19S lid of the 26S proteasome, plays a central role in the regulation of the E3-cullin RING ubiquitin ligases (CRLs) [PMID: 23288897]. The catalytic activity of the CSN complex is carried by subunit 5 (CSN5), also known as c-Jun activation domain-binding protein-1 (Jab1) [PMID: 23288897]. This entry is the C-terminal domain found in CSN5 proteins. CSN5, whose two C-terminal helices form an antiparallel hairpin, inserts its final C-terminal helix (helix II) into the central CSN6 framework at the core of the bundle. Deletion of the C-terminal helices has a pronounced effect on CSN integrity [PMID: 25043011].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.