Suppressor of hairless-like (IPR040159)

Short name: CLS_fam

Overlapping homologous superfamilies


Family relationships



The CLS family (CBF1/RBP-Jkappa/suppressor of hairless) consists of transcription factors essential for metazoan development, mainly due to their involvement in the Notch pathway [PMID: 29478922]. The members of this family recognize and bind to response element (GTGA/GGAA) in the promoters of the genes they regulate [PMID: 15288264]. Despite lacking the Notch pathway, CSL family members have been identified in fungal species. Schizosaccharomyces pombe has two CLS family proteins, Cbf11 and Cbf12, that bind the canonical CSL response element and play opposing roles in cell adhesion and coordination of cell and nuclear division [PMID: 23555033, PMID: 19101542].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.