Splicing factor 45 (IPR040052)

Short name: RBM17

Overlapping homologous superfamilies


Family relationships



This entry includes proteins with a G-patch domain and a RNA recognition motif domain, including mammalian splicing factor 45 (SPF45; also known as RNA-binding motif protein 17 or RBM17) and plant DNA-damage-repair/toleration protein DRT111 (also known as RSN2). SPF45 is an mRNA spliceosomal protein that is required for alternative splicing and the utilization of cryptic splice sites. The beta-110 mutation in the haemoglobin beta causes activation of a cryptic 3' splice site that is the cause of human beta-thalassemia (sickle-cell anemia) [PMID: 12015979]. DRT111 is also required for pre-mRNA splicing, particularly the mRNA for receptor-like kinase SNC4, which activates the defence response to microbial pathogens in plants [PMID: 25267732].

GO terms

Biological Process

GO:0043484 regulation of RNA splicing

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.