Protein melted-like (IPR039888)

Short name: Melted-like

Overlapping homologous superfamilies


Family relationships



This entry includes protein melted from fruit flies and its homologues. They contain a single C-terminal PH domain that is required for membrane targeting. Melted interacts with both Tsc1 and FOXO and can recruit them to the cell membrane [PMID: 16054033]. In vertebrates the melted protein homologue, veph, is expressed in the developing central nervous system [PMID: 15388229]. The human homologue VEPH1 (ventricular zone-expressed PH domain-containing protein homologue 1) has been shown to inhibit TGF-beta signaling by impeding the release of activated SMAD2 from TbetaRI [PMID: 26039994].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.