Family

Dickkopf-like protein (IPR039863)

Short name: DKK-like

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry includes Dickkopf-related proteins 1-4 (DKK1-4) and Dickkopf-like protein 1 (DKKL1). The Dickkopf (Dkk) proteins are cysteine-rich secretory proteins and highly conserved inhibitors of the canonical Wnt signaling pathway, which play key roles in many essential biological processes [PMID: 29925589]. DKKL1 is a acrosomal protein that affects in vitro fertilization, but the effect is attenuated in vivo [PMID: 19596312].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER