Family

FANCM/Mph1-like (IPR039686)

Short name: FANCM/Mph1-like

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry includes a group of evolutionarily conserved ATP-dependent DNA helicases/translocases including human FANCM (Fanconi anemia group M protein) and its homologues, such as Mph1 from S. cerevisiae and Fml1 from S. pombe.

FANCM is part of the FA complex that repair the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination [PMID: 29017571]. It also plays a critical role in the replication stress response [PMID: 28673972].

Mph1 can unwind Rad51 D-loops and extended D-loops [PMID: 26920759]. It has been shown to be regulated by the Smc5/6 complex [PMID: 19995966, PMID: 29281624].

Fml1 promotes Rad51-dependent gene conversion at stalled/blocked replication forks and limits crossing over during mitotic double-strand break repair [PMID: 18851838, PMID: 22844101].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0043140 ATP-dependent 3'-5' DNA helicase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER