Transcription elongation factor SPT5 (IPR039659)

Short name: SPT5

Overlapping homologous superfamilies


Family relationships


Transcription elongation factor Spt5 is found in both eukaryotes and archaea. Spt5 forms a heterodimer with Spt4 and collaborates with other transcription factors to pause or promote RNA polymerase II transcription elongation [PMID: 21467039]. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans, including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [PMID: 11182892].

GO terms

Biological Process

GO:0032784 regulation of DNA-templated transcription, elongation
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.