Domain

Dynein regulatory complex protein 1/2, N-terminal (IPR039505)

Short name: DRC1/2_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the N-terminal domain of dynein regulatory complex protein 1/2 (DRC1/2). DRC1 is a key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. It is required for the assembly and regulation of specific classes of inner dynein arm motors. It may also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending [PMID: 23354437].

Mutations of DRC1 gene cause Ciliary dyskinesia, primary, 21 (CILD21), which is a disorder characterised by abnormalities of motile cilia [PMID: 23354437].

DRC2, also known as CCDC65, is an essential component of the nexin-dynein regulatory complex [PMID: 24094744].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam