NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like (IPR039428)

Short name: NUOK/Mnh_C1-like

Overlapping homologous superfamilies


Family relationships


This entry includes NADH:ubiquinone oxidoreductase, chain 4L and bacterial Mnh complex subunit C. They share significant protein sequence similarity [PMID: 17293423].

ADH:ubiquinone oxidoreductase (complex I) (EC: is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. In eukaryotes, NADH:ubiquinone oxidoreductase, chain 4L is usually found in either mitochondria or chloroplasts as part of the respiratory-chain NADH dehydrogenase (also known as complex I or NADH-ubiquinone oxidoreductase), an oligomeric enzymatic complex [PMID: 15843018]. However, it is also found in bacteria [PMID: 18307315] and archaea [PMID: 10940377] where it is annotated as NuoK subunit.

Mnh subunit C1 is a cation antiporter, involved in K(+) and Na(+) excretion [PMID: 17293423].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.