Family

Transcriptional regulatory protein WalR-like (IPR039420)

Short name: WalR-like

Overlapping homologous superfamilies

Family relationships

Description

This family contains proteins that have a signal transduction response regulator receiver domain at the N terminus and a OmpR/PhoB-type DNA-binding domain at the C terminus. Homologues are predominantly from bacteria, but also eukaryotes and archaea. Members of the family are frequently part of a two-component regulatory system, including:

  • Transcriptional regulatory protein WalR, a member of the two-component regulatory system with WalK involved in the regulation of the ftsAZ operon and others [PMID: 10878122]
  • Heme response regulator HssR, a member of the two-component regulatory system with HssS involved in intracellular heme homeostasis and tempering of staphylococcal virulence.
  • Response regulator protein GraR, a member of the two-component regulatory system with GraS involved in resistance against cationic antimicrobial peptides [PMID: 17502406]
  • Response regulator MprA, a member of the two-component regulatory system with MprB which contributes to maintaining a persistent infection in the host [PMID: 14638785]
  • Response regulator ArlR, a member of the two-component regulatory system with ArlS involved in the regulation of adhesion, autolysis, multidrug resistance and virulence [PMID: 10869073]
  • Response regulator SaeR, a member of the two-component regulatory system with SaeS involved in the regulation of staphylococcal virulence factors [PMID: 14563862]

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER