Family

Deltex family (IPR039398)

Short name: Deltex_fam

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The deltex family of proteins is involved in the regulation of Notch signaling, and therefore may play roles in cell-to-cell communications that regulate mechanisms determining cell fate [PMID: 9590294]. They have a central RING-type zinc finger domain and contain a C-terminal domain that is also found in other domain architectures. Deltex-1 (DTX1) contains a RING finger and two WWE domains, indicating that it may be an E3 ubiquitin ligase [PMID: 20208568]. Human deltex 3-like, which contains an additional N-terminal domain (presumably with ubiquitin ligase activity) is also described as E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein (BBAP), or rhysin-2. DTX3L mediates monoubiquitination of K91 of histone H4 in response to DNA damage [PMID: 22411408, PMID: 12670957].

GO terms

Biological Process

GO:0007219 Notch signaling pathway
GO:0016567 protein ubiquitination

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER