RagA/B (IPR039397)

Short name: RagA/B

Overlapping homologous superfamilies

Family relationships


RagA and RagB are closely related Rag GTPases (ras-related GTP-binding protein A and B) that constitute a unique subgroup of the Ras superfamily [PMID: 15731001], and are functional homologues of Saccharomyces cerevisiae Gtr1 [PMID: 9394008]. They function by forming heterodimers with RagC or RagD, and similarly, Gtr1 dimerizes with Gtr2, through the carboxy-terminal segments. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling [PMID: 23242467], exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7 [PMID: 20381137].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.