Acetolactate synthase large subunit, TPP binding domain (IPR039368)

Short name: AHAS_TPP

Overlapping homologous superfamilies


Domain relationships


This entry represents the thiamine pyrophosphate (TPP) binding domain found in the acetohydroxyacid synthase (AHAS) subfamily members. AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate. 2-Acetolactate is the precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. In addition to requiring TPP and a divalent metal ion as cofactors, AHAS requires FAD [PMID: 2989783, PMID: 9655946].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030976 thiamine pyrophosphate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.