Family

Inner centromere protein (IPR039130)

Short name: INCENP

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Inner centromere protein (INCENP) is a component of the chromosomal passenger complex (CPC), which is an important regulator of mitosis. CPC ensures correct alignment and segregation of chromosomes at the centromere. INCENT interacts with several other CPC subunits [PMID: 15316025, PMID: 12925766, PMID: 27332895] and it activates subunits AURKB and AURKC [PMID: 27332895]; it also interacts with the tubulin beta chain [PMID: 11139336]. Two paralogues exist in Xenopus named INCEP A and B.

GO terms

Biological Process

GO:0000070 mitotic sister chromatid segregation
GO:1902412 regulation of mitotic cytokinesis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER