Family

Elongin B (IPR039049)

Short name: ELOB

Overlapping homologous superfamilies

Family relationships

None.

Description

Elongin B is a subunit of the transcription factor B (SIII) complex, which activates elongation by mammalian RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits. Elongin A functions as the transcriptionally active component of Elongin (SIII), while Elongin B and C are regulatory subunits [PMID: 7660129].

Elongin B has been shown to form complex with Elongin C and VHL (von Hippel-Lindau, a tumour suppressor). This complex, known as the VBC complex, shows structural similarities with the SCF complex [PMID: 10205047]. The VBC complex binds to hypoxia-inducible factor 1alpha (HIF-1alpha) via VHL and targets HIF-1alpha for ubiquitination [PMID: 10878807].

GO terms

Biological Process

GO:0006368 transcription elongation from RNA polymerase II promoter

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030891 VCB complex
GO:0070449 elongin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER