Family

PDPK1 family (IPR039046)

Short name: PDPK1

Overlapping homologous superfamilies

Family relationships

None.

Description

This family includes 3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) and related kinases from yeast: Pkh1 and Pkh2 from S. cerevisiae, which function similarly to PDK1 [PMID: 10074427], and Ksg1 [PMID: 14625898] and Ppk21 from S. pombe [PMID: 15857958].

PDK1 is the kinase responsible for the phosphorylation of PKB/Akt on the activation loop, at threonine 308, which is essential for Akt activation [PMID: 9094314, PMID: 9895304]. Beyond Akt, PDK1 is responsible for the phosphorylation of many other AGC kinases including serum/glucocorticoid regulated kinase (SGK) [PMID: 10191262] and the members of protein kinase C (PKC) family [PMID: 9748166]. PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc [PMID: 28473254]. It is a key regulator of cell migration and tumor invasion [PMID: 28287465]. PDK1 binds to the insulin receptor, followed by tyrosine phosphorylation of PDK1 by the insulin receptor, which is necessary for insulin metabolic signaling [PMID: 16314505]. Deficiency of PDK1 in liver results in glucose intolerance [PMID: 15554902].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER