Family

PDK/BCKDK protein kinase (IPR039028)

Short name: BCKD/PDK

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry includes [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase (BCKDK) and [Pyruvate dehydrogenase (acetyl-transferring)] kinase (PDK).

BCKDK catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways [PMID: 24449431].

Pyruvate dehydrogenase kinase inhibits the pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism [PMID: 11486000].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004672 protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER