Insulin receptor substrate (IPR039011)

Short name: IRS

Overlapping homologous superfamilies


Family relationships



The insulin receptor substrate protein (IRS) family consists of IRS-1, -2, -3 and -4. IRS family proteins are adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways [PMID: 24039912]. They are important regulatory factors in insulin signaling pathways [PMID: 12169433]. When tyrosine is phosphorylated by the activated insulin receptor, the IRS proteins recruit and activate various adapter molecules or enzymes, such as phosphoinositide 3-kinase(PI3K) and mitogen-activated protein kinase (MAPK) to facilitate glucose uptake [PMID: 27514532], lipid metabolism [PMID: 28213130, PMID: 16814735] and cell proliferation [PMID: 28101572, PMID: 27876799].

IRS proteins consist of two highly conserved domains in the N-terminal region, a pleckstrin homology (PH) domain and a phosphotyrosine-binding (PTB) domain, followed by a long, non-conserved C-terminal domain.

GO terms

Biological Process

GO:0008286 insulin receptor signaling pathway

Molecular Function

GO:0005158 insulin receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.