Molybdopterin biosynthesis protein MoeA-like (IPR038987)

Short name: MoeA-like

Overlapping homologous superfamilies

Family relationships



Eukaryotic and prokaryotic molybdoenzymes require a molybdopterin cofactor (MoCF or Moco) for their activity. The biosynthesis of this cofactor involves a complex multistep enzymatic pathway. In bacteria, The final step in MoCF synthesis is the attachment of mononuclear Mo to MPT, a process that requires MoeA and which is enhanced by MogA in an Mg2 ATP-dependent manner [PMID: 17198377].

In eukaryotes, MogA and MoeA are fused into a single polypeptide chain, such as in Drosophila protein cinnamon [PMID: 8088525]. The corresponding mammalian protein gephyrin has also been implicated in the anchoring of glycinergic receptors to the cytoskeleton at inhibitory synapses [PMID: 26613940, PMID: 11525167].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.