Homologous Superfamily

GT29-like superfamiliy (IPR038578)

Short name: GT29-like_sf

Overlapping entries

Description

Glycosyltransferase family 29 (GT29) comprises enzymes with a number of known activities; sialyltransferase (EC:2.4.99), beta-galactosamide alpha-2,6-sialyltransferase (EC:2.4.99.1), alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC:2.4.99.3), beta-galactoside alpha-2,3-sialyltransferase (EC:2.4.99.4), N-acetyllactosaminide alpha-2,3-sialyltransferase (EC:2.4.99.6), alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (EC:2.4.99.8); lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9). These enzymes use a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar.

Sialyltransferase may be responsible for the synthesis of the sequence NEUAC-Alpha-2,3-GAL-Beta-1,3-GALNAC-, found on sugar chains O-linked to thr or ser and also as a terminal sequenec on certain gagnliosides. These enzymes catalyse sialyltransfer reactions during glycosylation, and are type II membrane proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D