Homologous Superfamily

Atg6/Beclin C-terminal domain superfamily (IPR038274)

Short name: Atg6/Beclin_C_sf

Overlapping entries

Description

In yeasts, vacuolar protein sorting-associated protein 30 (Vps30), also known as autophagy-related protein 6 (Atg6), is a common component of two distinct phosphatidylinositol 3-kinase complexes. In complex I, Atg14 links Vps30 to Vps34 lipid kinase and plays a specific role in autophagy, while in complex II, Vps38 links Vps30 to Vps34 and plays an important role in vacuolar protein sorting [PMID: 22437838]. The C-terminal of Vps30 contains a globular fold comprised of three beta-sheet-alpha-helix repeats and is required for autophagy through the targeting of complex I to the pre-autophagosomal structure. The N-terminal of Vps30 is required for vacuolar protein sorting [PMID: 22437838].

Beclin, the mammalian homologue of yeast Atg6/Vps30, is a tumour suppressor that coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes [PMID: 21311563, PMID: 22170155].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D