Homologous Superfamily

DNA polymerase alpha, zinc finger domain superfamily (IPR038256)

Short name: Pol_alpha_znc_sf

Overlapping entries


The DNA Polymerase alpha zinc finger domain adopts an alpha-helix-like structure, followed by three turns, all of which involve proline. The resulting motif is a helix-turn-helix motif, in contrast to other zinc finger domains, which show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. The function of this domain is uncertain: it has been proposed that the zinc finger motif may be an essential part of the DNA binding domain [PMID: 14499601].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.