Homologous Superfamily

Dicer dimerisation domain superfamily (IPR038248)

Short name: Dicer_dimer_sf

Overlapping entries


This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules. It is essential for the activity of Dicer [PMID: 16424907, PMID: 17666393]. It is a divergent double stranded RNA-binding domain [PMID: 16954143]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [PMID: 20106953]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [PMID: 20106953].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.