Family

Nucleosome-remodeling factor subunit BPTF (IPR038028)

Short name: BPTF

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry includes the nucleosome-remodeling factor subunits BPTF (vertebrates) and NURF301 (Drosophila melanogaster), which are components of the NURF (nucleosome-remodeling factor) complex [PMID: 11583616, PMID: 14609955]. The NURF complex catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin [PMID: 12502740]. The HMGA/HMGI(Y)-like DNA-binding site of NURF301 facilitates nucleosome sliding [PMID: 11583616]. BPTF binds histone H3K4me3 via its PHD zinc finger domain [PMID: 16728976], and interacts with the myc-associated zinc finger protein MAZ, altering its transcriptional activity, [PMID: 10727212] and the Kelch-like Ech-associated protein KEAP1 [PMID: 15379550].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016589 NURF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER