Homologous Superfamily

Phosphoribosyl-AMP cyclohydrolase domain superfamily (IPR038019)

Short name: PRib_AMP_CycHydrolase_sf

Overlapping entries

Description

The phosphoribosyl-AMP cyclohydrolase EC:3.5.4.19 catalyses the third step in the histidine (his) biosynthetic pathway:

5-phosphoribosyl-AMP + H2O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phospho-ribosyl) imidazole-4-carboxamide

It requires Zn2+ ions for activity [PMID: 9931020].

Methanobacterium phosphoribosyl-AMP cyclohydrolase HisI is a dimer; each monomer is composed of four beta-hairpins [PMID: 16042384].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY