Transcription factor COE, IPT domain (IPR038006)

Short name: COE_IPT

Overlapping homologous superfamilies

Domain relationships

  • IPT domain (IPR002909)
    • Transcription factor COE, IPT domain (IPR038006)


This entry represents the IPT domain of the COE family members (Col/Olf-1/EBF), which are non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown [PMID: 11578857, PMID: 12446759].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.