Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (IPR037981)

Short name: PPP1CC

Overlapping homologous superfamilies

Family relationships



Serine/threonine-protein phosphatase PP1 (EC: is a complex of a catalytic subunit, either PPP1CA, PPP1CB or PPP1CC, with one or more regulatory or targeting subunits. Example targeting subunits are PPP1R12A and PPP1R12C, which mediate binding of PP1 to myosin [PMID: 15124925,PMID: 11399775,PMID: 20354225]; PPP1R3A, which mediates binding to glycogen in the skeletal muscle [PMID: 1651919]; PPP1R7, [PMID: 12226088]; PPP1R15A, which mediates binding to EIF2S1 [PMID: 11564868]. The phosphatase associates with any one of many other regulatory proteins to form a complex that dephosphorylates a specific target protein. For example, centrosome splitting is regulated by the association of NEK2 with PP1 via the PPP1CA subunit [PMID: 17283141], binding to ATG16L1 antagonizes casein kinase 2-mediated phosphorylation of ATG16L1 affecting the fate of cadiomyocytes [PMID: 26083323] and association with TNF-a induces phosphorylation of FOXP3 which controls regulatory T cell function [PMID: 23396208]. PP1 is required for the cell cycle [PMID: 21712997], cell division, glycogen metabolism [PMID: 1651919], muscle contraction [PMID: 15124925] and protein synthesis. PPP1CA and PPP1CB are components of the PTW/PP1 phosphatase complex [PMID: 20516061].

This entry includes the catalytic subunit gamma (PPP1CC) from mammals, PP1-alpha from C. elegans, Dis2 from fission yeasts and Glc7 from budding yeasts. Glc7 is also a component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB [PMID: 12819204].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004722 protein serine/threonine phosphatase activity

Cellular Component

GO:0000164 protein phosphatase type 1 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.