SH3PXD2, PX domain (IPR037961)

Short name: SH3PXD2_PX

Overlapping homologous superfamilies

Domain relationships


This entry represents the PX domain of SH3PXD2A and SH3PXD2B. The PX domain is involved in targeting of proteins to phosphoinositide-enriched membranes, and may also be involved in protein-protein interaction [PMID: 11684018].

SH3PXD2A, also known as Fish or Tks5, is a scaffold protein with five SH3 domains and one PX domain. It is required for podosome formation, for degradation of the extracellular matrix, and for invasion of some cancer cells [PMID: 15710328, PMID: 25826475]. SH3PXD2A binding partners include ADAM-family metalloproteases [PMID: 12615925] and Nck adaptor proteins [PMID: 19596797].

SH3 and PX domain-containing protein 2B (SH3PXD2B, also known as Fad49 or Tks4) is an adaptor protein required for functional podosome formation [PMID: 19144821]. It binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides [PMID: 19755710]. It regulates epidermal growth factor-dependent cell migration [PMID: 22829589] and has been linked to cancer [PMID: 22260678]. Mutations in the SH3PXD2B gene cause Frank-ter Haar syndrome, a rare disease characterised by abnormalities that affect bone, heart, and eye development [PMID: 20137777]. It contains an N-terminal Phox homology (PX) domain and four SH3 domains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.