Domain

ARHGEF28, PH domain (IPR037819)

Short name: ARHGEF28_PH

Overlapping homologous superfamilies

Domain relationships

Description

ARHGEF28 (also called RIP2 or p190RhoGEF) belongs to regulator of G-protein signaling (RGS) domain-containing RhoGEFs that are RhoA-selective and directly activated by the Galpha12/13 family of heterotrimeric G proteins. In addition to the Dbl homology (DH)-PH domain, p190RhoGEF contains an N-terminal C1 (Protein kinase C conserved region 1) domain. The DH-PH domains bind and catalyze the exchange of GDP for GTP on RhoA [PMID: 22649559].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD