Small G protein signalling modulator 1/2, PH domain (IPR037745)

Short name: SGSM1/2

Overlapping homologous superfamilies


Domain relationships


Small G-protein signalling modulator 1/2 (also known as RUTBC2/1) bind to Rab9A via their Pleckstrin homology (PH) domain [PMID: 22637480, PMID: 26620560]. RUTBC1 stimulates GTP hydrolysis by Rab32 and Rab33B [PMID: 26620560], while RUTBC2 appears to be a GAP for Rab36, Rab9A and associated proteins controling the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi [PMID: 25220469, PMID: 22637480, PMID: 17509819].

This entry represents the PH domain of RUTBC1/2.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.