Large-conductance mechanosensitive channel/anditomin synthesis protein L (IPR037673)

Short name: MSC/AndL

Overlapping homologous superfamilies

Family relationships


Mechanosensitive ion channels (MscL) play a critical role in transducing physical stresses at the cell membrane into an electrochemical response. MscL is a protein which forms a channel organised as a homopentamer, with each subunit containing two transmembrane regions [PMID: 9856938]. Prokaryotes harbor a large-conductance mechanosensitive channel (gene mscL) that opens in response to stretch forces in the membrane lipid bilayer and may participate in the regulation of osmotic pressure changes within the cell [PMID: 9632260].

This family also includes anditomin synthesis protein L (AndL), which is part of the gene cluster that mediates the biosynthesis of anditomin. Its role of in this pathway is not known [PMID: 25216349].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.