Mannan-binding lectin-associated serine peptidase 2 (IPR037571)

Short name: MASP2

Overlapping homologous superfamilies


Family relationships


This entry represents mannan-binding lectin-associated serine peptidase 2 (MASP2; MEROPS identifier S01.229), a serine endopeptidase from family S1 (chymotrypsin family) which is a component in the activation of complement in the lectin pathway. MASP2 has trypsin-like specificity and it processes complement components C2 and C4 [PMID: 10946292]. The fragments released, C2a and C4b, form the C3/C5 convertase. The specificity of MASP2 is identical to that of complement component C1s, but from the solved tertiary structure that enzyme-substrate interactions are different [PMID: 15364579]. MASP2 is inhibited by C1 inhibitor [PMID: 10946292]. MASP2 forms a homodimer, stabilized by two Ca2+ ions, before it binds to mannose-binding protein C [PMID: 15117939]. MASP2 autoactivates itself to a two-chain form.

GO terms

Biological Process

GO:0001867 complement activation, lectin pathway

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.