Complement component C6 (IPR037563)

Short name: Complement_C6

Overlapping homologous superfamilies


Family relationships


This entry represents complement component C6, which is one of the components that forms the membrane-lytic ring (the membrane attack complex, MAC). MAC consists of C5b, which binds sequentially to C6, C7, C8 and 12-14 copies of the pore-forming subunit C9 [PMID: 22267737]. The structure of C6 shows that the central domain is perforin-like [PMID: 22267737].

GO terms

Biological Process

GO:0006956 complement activation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005579 membrane attack complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.