Envelope glycoprotein Gp160 (IPR037527)

Short name: Gp160

Overlapping homologous superfamilies


Family relationships



The envelope glycoprotein Gp160 of HIV1 and simian immunodeficiency virus (SIV) is cleaved into the surface protein Gp120 and the transmembrane protein Gp41 [PMID: 15729334]. This entry represents the full length Gp160. Gp160 oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, Gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce Gp120 and Gp41 [PMID: 28250125].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.