Family

Envelope glycoprotein Gp160 (IPR037527)

Short name: Gp160

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The envelope glycoprotein Gp160 of HIV1 and simian immunodeficiency virus (SIV) is cleaved into the surface protein Gp120 and the transmembrane protein Gp41 [PMID: 15729334]. This entry represents the full length Gp160. Gp160 oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, Gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce Gp120 and Gp41 [PMID: 28250125].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP