Family

Melanoma-associated antigen (IPR037445)

Short name: MAGE

Overlapping homologous superfamilies

None.

Family relationships

Description

The melanoma antigen (MAGE) protein family contains more than 25 members that share a conserved MAGE homology domain (MHD) [PMID: 11454705].

Proteins known to contain a MAGE domain are listed below:

  • Human MAGE-A, -B and -C proteins. MAGE-A, -B and -C genes are silent in all normal tissues with the exception of testis.
  • Human MAGE-D to -L proteins. MAGE-D to -L genes are expressed in normal adult tissues.
  • Mouse Mage-a and -b proteins.
  • Mouse Mage-d, -e, -g, -h, -k and -l.
  • Mammalian Necdin. The human Necdin gene is a candidate for the Prader-Willi syndrome.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER