Family

Neurexin (IPR037440)

Short name: Neurexin

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Neurexins (NRXNs) are presynaptic transmembrane proteins with a major role in cell-cell interactions across the synapse. There are three NRXNs genes (NRXN 1-3) in vertebrates, each of which has both an upstream promoter that is used to generate the larger alpha-NRXNs and a downstream promoter that is used to generate the shorter beta-NRXNs [PMID: 12036300]. Alpha-neurexins (I alpha, II alpha, and III alpha) and beta-neurexins (I beta and II beta) have identical C termini but distinct N termini [PMID: 8163501]. Alpha-neurexins contain five LNS and three EGF domains at the N terminus that are absent from beta-neurexins [PMID: 9325340].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER