Pleckstrin 1, DEP domain (IPR037371)

Short name: PLEK1_DEP

Overlapping homologous superfamilies

Domain relationships

  • DEP domain (IPR000591)
    • Pleckstrin 1, DEP domain (IPR037371)


Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, mainly by protein kinase C [PMID: 15573383]. Pleckstrin-like proteins contain a central DEP domain, flanked by 2 PH (pleckstrin homology) domains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.