Exonuclease-1, H3TH domain (IPR037315)

Short name: EXO1_H3TH

Overlapping homologous superfamilies

Domain relationships



Exonuclease-1 (EXO1) is a 5'-3' exonuclease that functions in DNA mismatch repair (MMR), double-strand break repair, replication and recombination [PMID: 16143102, PMID: 14676842, PMID: 12531018]. It also possesses a flap-endonuclease activity [PMID: 12531018, PMID: 10608837].

This entry represents the H3TH (helix-3-turn-helix) domain of EXO1. The H3TH domain has an extended loop with at least three turns between the first two helices, and only three of the four helices appear to be conserved. Together with the helical arch and network of amino acids interacting with metal binding ions, the H3TH region defines a positively charged active-site DNA-binding groove in structure-specific 5' nucleases [PMID: 12706715].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0035312 5'-3' exodeoxyribonuclease activity
GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.