ASC domain superfamily (IPR037256)
Short name: ASC_dom_sf
- Association with the SNF1 complex (ASC) domain (IPR006828)
- SNF1-related protein kinase regulatory subunit beta-3 (IPR030067)
- SNF1-related protein kinase regulatory subunit beta-2 (IPR030070)
- SNF1 protein kinase subunit beta-1 (IPR030073)
- SNF1 protein kinase subunit beta-2/beta-3 (IPR030077)
- SNF1-related protein kinase regulatory subunit beta-1 (IPR037170)
- 5'-AMP-activated protein kinase subunit beta (IPR039160)
Association with the SNF1 complex (ASC) domain is found in the Sip1/Sip2/Gal83/AMPKbeta subunits of the SNF1/AMP-activated protein kinase (AMPK) complex [PMID: 11252725]. SNF1/AMPK are heterotrimeric enzymes composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit [PMID: 9121458]. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83 [PMID: 7813428, PMID: 10990457]. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits. The ASC domain is required for interaction with Snf4 [PMID: 11252725, PMID: 9121458].
The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [PMID: 17981722, PMID: 10207618]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources.
Structurally, this domain comprises three short helices and 3-stranded meander beta-sheet which makes extensive intermolecular interactions.
- SSF160219 (SSF160219)