Homologous Superfamily

Rel homology domain (RHD), DNA-binding domain superfamily (IPR037059)

Short name: RHD_DNA_bind_dom_sf

Overlapping entries


The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish, NFAT, among others. The RHD is composed of two structural domains: the N-terminal DNA binding domain that is similar to that found in P53, the C-terminal domain has an immunoglobulin-like fold (See PF16179) that functions as a dimerisation domain. This entry represents the N-terminal DNA binding domain superfamily [PMID: 17869269].

Some of these transcription factors appear to form multi-protein DNA-bound complexes [PMID: 9794820]. Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors, acting to modulate the expression of their target genes [PMID: 15516339]. The RHD is composed of two immunoglobulin-like beta-barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases; the C-terminal dimerisation domain contains the site for interaction with I-kappaB [PMID: 7830764].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.