Homologous Superfamily

E3-binding domain superfamily (IPR036625)

Short name: E3-bd_dom_sf

Overlapping entries


A small domain of the E2 subunit of 2-oxo-acid dehydrogenases that is responsible for the binding of the E3 subunit. Proteins containing this domain include the branched-chain alpha-keto acid dehydrogenase complex of bacteria, which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide; and the E-3 binding protein of eukaryotic pyruvate dehydrogenase [PMID: 8805537].

The structure of the E3-binding domain has three helices with a close bundle fold and right-handed twist going up-and-down.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.